Turning the jarring juxtaposition of her nasally New York accent and fashion model looks into an endearing signature persona, actress Fran Drescher found fame as a brassy and sassy Lucille Ball-like character on one of the most popular sitcoms of the 1990s. After making her minor, but memorable film debut in "Saturday Night Fever" (1977), Drescher was seen regularly in small parts in films like "Ragtime" (1981), "Doctor Detroit" (1983) and "This is Spinal Tap" (1984). Unsuccessful attempts at landing a television series of her own, which included "Charmed Lives" (ABC, 1986) and "Princesses" (CBS, 1991), eventually gave way to sitcom stardom as the outspoken au pair Fran Fine on the hit comedy "The Nanny" (CBS, 1993-99). The show's popularity also enabled its star to pursue lead roles in such feature films as "The Beautician and the Beast" (1997). Drescher later became an awareness advocate after being diagnosed with uterine cancer in 2000, an illness from which she fully recovered following aggressive surgery. Continuing to mine personal experience for her creative endeavors, Drescher returned to television in "Happily Divorced" (TV Land, 2011-12), a sitcom inspired by her real life ex-husband coming out to Drescher as a gay man years earlier. A perfect example of playing to one's strengths, Drescher turned her adenoidal yet adorable personality into a veritable cottage industry as an actress, producer, writer and wellness advocate.