Film producer and studio chief Nina Jacobson experienced a mercurial rise to power, followed by a precipitous fall from grace and a professional rebirth - all before the age of 50. Fresh out of college, Jacobson became the head of Joel Silver's Silver Pictures prior to transitioning over to Universal, where as a senior vice president of production, she oversaw such features as "Dazed & Confused" (1993) and "Twelve Monkeys" (1995). Later credited with the inspiration for the animated-fantasy "Antz" (1998) while at DreamWorks SKG, she broke through the glass ceiling when her latest find, M. Night Shyamalan's "The Sixth Sense" (1999), helped her land the position of President of Production at Disney Motion Pictures. During her time there, Jacobson was responsible for shepherding such hits as "The Princess Diaries" (2001), as well as the "Pirates of the Caribbean" (2003) and "Chronicles of Narnia" (2005) franchises. Despite being named one of "The World's 100 Most Powerful Women" by Forbes magazine in 2005, Jacobson was unceremoniously fired at Disney during a top-to-bottom restructuring one year later. Down, but never out, she soon came back as the head of her own production company and launched yet another popular franchise with "Diary of a Wimpy Kid" (2010). Aggressive, intuitive and supremely competent, Jacobson had clearly proven herself to be a long-term Hollywood power player.